Search results for "Hormone refractory"

showing 3 items of 3 documents

Oral chemotherapy in hormone-refractory prostate carcinoma patients unwilling to be admitted to hospital.

2008

<i>Objectives:</i> To investigate the safety and efficacy in terms of PSA response of a low-dose oral combination of estramustine phosphate (EMP) and etoposide (VP16) in hormone- refractory prostate cancer (HRPC) patients. Well-tolerated outpatient chemotherapy regimens for patients unfit and/or unwilling to be admitted to hospital are needed. <i>Methods:</i> Fifty-six HRPC patients with metastatic disease (median age 75 years) were randomized between arm A (daily oral EMP 10 mg/kg, in 3 doses) and arm B (28-day cycle with low-dose EMP 3 mg/kg once daily plus VP16 25 mg/m<sup>2</sup> once daily on days 1 through 14). Baseline characteristics between the t…

OncologyMalemedicine.medical_specialtyHormone refractoryOral chemotherapyUrologyUrologyPsa responseAdministration OralAntineoplastic AgentsAdenocarcinomaProstate cancerhormone-refractory prostate carcinoma Oral chemotherapyInternal medicinemedicineEstramustine phosphateHumansEtoposideAgedEtoposideAged 80 and overbusiness.industryProstatic NeoplasmsProstate carcinomaMiddle Agedmedicine.diseaseHospitalizationEstramustinePatient Compliancebusinessmedicine.drugHormoneUrologia internationalis
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PSA and second-line therapy of hormone refractory prostate carcinoma

2001

The aim of the present study was to correlate PSA response with subjective response (bone pain and performance status), in patients treated for hormone refractory carcinoma of the prostate. Twenty-four patients were introduced into the study. Median PSA was 198 ng/ml. Symptom score, performance status and PSA were monitored monthly for 3 months and then 3-monthly. Sixteen patients (66%) showed a PSA response (median value 10 ng/ml). In 8 patients (33%) PSA was 4 ng/ml. In conclusion, PSA response is not always related to subjective improvement and does not always implicate a beneficial effect of the therapy for the patient. Copyright © 2001 S. Karger AG, Basel.

OncologyMalemedicine.medical_specialtyPathologyHormone refractorymedicine.drug_classUrologyAdenocarcinomaAntiandrogenSettore MED/24 - UrologiaPSAProstateInternal medicineCarcinomamedicineHumansHormone refractoryBone painAgedAged 80 and overPerformance statusbusiness.industryProstateProstatic NeoplasmsMiddle AgedProstate-Specific Antigenmedicine.diseaseProstate-specific antigenmedicine.anatomical_structureProstatic adenocarcinomaAdenocarcinomamedicine.symptombusiness
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Out-patient low-dose oral chemotherapy in hormone refractory prostate carcinoma (HRPC) patients unfit for hospital admittance.

2008

Objectives: Well tolerated out-patient regimens for HRPC chemotherapy in elderly patients with geographical difficulties and/or unwilling hospital admission are needed. The aim of the present study was to investigate the safety and efficacy of a low-dose oral combination of estramustine phosphate (EMP) and etoposide (VP16). Patients: Fifty-six HRPC patients, median age 75 years, were randomized between daily EMP (10mg/kg) – arm A, and low-dose EMP (3mg/kg) plus VP16 (25mg/mq) 2 weeks monthly – arm B. Randomization ratio was 2:3. Median PSA was 41.1 ng/ml. Baseline characteristics between the 2 groups were similar. LHRH therapy was maintained. Antiandrogen was stopped one month before entry.…

Oncologymedicine.medical_specialtyChemotherapyAdmittanceHormone refractoryOral chemotherapybusiness.industryUrologymedicine.medical_treatmentLow doseUrologyProstate carcinomaInternal medicinemedicinebusinesshormone refractory prostate carcinoma chemotherapy
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